Model for Microcapsule Drug Release with Ultrasound-Activated Enhancement

Selectivity enhancement using permselective microcapsule

Multi-competitive enzymatic reactions were performed to determine the selectivity properties of enzymes immobilised in polyacrylamide-alginate (pAAm-Alg) microcapsules. The transesterification of fatty acid ethyl esters of different chain lengths (C2–C14) with various alcohols catalysed by the enzyme lipase Mucor Miehei was chosen as a test system. While the free enzyme exhibited higher selecti...

Micro-patterned drug delivery device for light-activated drug release.

BACKGROUND The primary goal of this study was the fabrication, long-term stability, and measured release of a marker dye from a micro-patterned drug delivery device using (i) mechanical puncture and (ii) photodisruption with an ophthalmic Nd:YAG laser. MATERIALS AND METHODS A drug delivery device was made from a transparent bio-compatible polymer. The device consisted of two 2.6 mm diameter r...

Microcapsule Drug Delivery Device for Treatment

Controlled-release drug delivery systems are capable of treating debilitating diseases, including cancer. Brain cancer, in particular glioblastoma multiforme (GBM), is an extremely invasive cancer with a dismal prognosis. The use of drugs capable of crossing the blood-brain barrier has shown modest prolongation in patient survival, but not without unsatisfactory systemic, dose-limiting toxicity...

Protective effect of N-acetylcysteine activated carbon release microcapsule on myocardial ischemia-reperfusion injury in rats

With the development of science and technology, and development of artery bypass, methods such as cardiopulmonary cerebral resuscitation have been practiced in recent years. Despite this, some methods fail to promote or recover the function of tissues and organs, and in some cases, may aggravate dysfunction and structural damage to tissues. The latter is typical of ischemia-reperfusion (IR) inj...

Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release